Genetic tests possible for Substance Abuse
News Wise - are already genetic tests of blood samples for the diagnosis of certain diseases and even personalize treatment.Now, it is possible to develop similar tests show that the potential of a person, depending on nicotine or marijuana or personality disorder antisocial, University of Iowa researchers report online March 6 in the American Journal of Medical Genetics.
These tests would not dictate, substance dependence or behavioural disorders have problems, such as genes do not work in isolation but are influenced by other genes and environmental factors, said the author of the study lead Robert Philibert, MD, Ph.D., professor of psychiatry at the user interface - Lucille Roy J. and A. Carver College of Medicine.
“Our study indicates that the analysis of gene expression in the blood might indicate that if a person is vulnerable to a behavioural disorder. After a certain expression of the gene modification is not itself start of principle that a person is a certain way. It may, however, show greater biological basis for the hosting of behaviors such as smoking and alcohol or marijuana, “said Philibert.
“The most important is not whether you have the gene, but if the gene expressed and what other environmental factors may play a role. Genetic change in itself is not deterministic,” he added.
In a study published online on March 6 Philibert and his colleagues reported a potential blood test for panic disorder. The disorder and panic of a study on drug abuse uses data from studies of the adoption of Iowa, which Remi Cadoret, MD, a user interface internationally renowned professor of psychiatry, east who died in 2005.
In this latest study, researchers have found differences in the genes of human beings with a history of smoking compared with no such history. In total, more than 579 genes expressed and less than 584 genes were expressed in human resources, had smoked.
Philibert and his colleagues recognized, both the potential benefits and ethical concerns that might stem cells for research.
“On the one hand, we can say that this is an ethical risk in search of people, perhaps vulnerable to abuse alcohol or smoking and how insurance companies, for example That the use of information, “said Tracy Gunter, MD, Professor of Psychiatry user interface and a study co-author. “But it could benefit from early identification of people at risk practices such as substance abuse.
“The doctors could individual prevention and personalized treatment plans, and knowledge of a serious disturbance to give greater knowledge of each and hence its vulnerability greater responsibility to manage,” Gunter said.
The technical examination of blood is called “transcription profiles,” said Anup Madan complement IU Assistant professor of neurosurgery and assistant professor at the Institute Systems Biology in Seattle.
“Profiling a look in the transcription of genes - almost 30000 of them - both. Label We have all the genes expressed by Keywords fluorescent, and changes in the intensity of fluorescence are used for labelling of differential genes, “said Madan.
“We can see if it is a model of a disease genes. Over time, we can build a map and see what happened and define the relationship between genes,” he added.
The team used samples from six subjects in the adoption of Iowa and nine studies controls for the first profiling. Then uses data from 94 adoption study subjects, the model results in the gene.
Madan acknowledged the ethical aspects, but the potential benefits for individuals’ health care.
“Blood is a substance which, by all other organs, and we have the potential for a window in the prevention and treatment of diseases,” he said. “The practitioners and patients should be consequences. Fortunately, we have developed well in advance of tests and will be commercially available to think and discuss themes.
Gunter said: “Only because we are dealing with the deep biology of the individual does not automatically mean the results are negative.”
Researchers studying the data they have now, in detail and see how they compared the results of other studies.
The study was funded in part by grants from the National Institutes of Health.
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